Proteins/UNIPROT:D6RGH6

MCIDAS

ProteinUNIPROT:D6RGH6

Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1..

Function from UniProtKB (D6RGH6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

ciliary dyskinesia, primary, 42 has a germline basis in MCIDASDiseaseGenCC HGNC:40050|MONDO:0032872Inferred only
primary ciliary dyskinesia has a germline basis in MCIDASDiseaseGenCC HGNC:40050|MONDO:0016575Inferred only

Statements

11 statements

11 statements · 4 reference databases · Subject: MCIDAS · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

GMNN interacts with MCIDASProteinHetionet hetionet:interacts:345643-51053Inferred only
MCIDAS participates in Assembly of the 9+2 motile ciliaPathwayReactome R-HSA-9975924Inferred only
MCIDAS participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
MCIDAS participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
MCIDAS participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
MCIDAS participates in Transcriptional regulation of multiciliogenesisPathwayReactome R-HSA-9945556Inferred only
MCIDAS regulates positive regulation of DNA-templated transcriptionBiological processgene ontology D6RGH6|GO:0045893Inferred only
MCIDAS regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology D6RGH6|GO:0045944Inferred only
MCIDAS regulates regulation of cilium assemblyBiological processgene ontology D6RGH6|GO:1902017Inferred only
MCIDAS regulates regulation of DNA-templated DNA replication initiationBiological processgene ontology D6RGH6|GO:0030174Inferred only
MCIDAS regulates regulation of mitotic cell cycleBiological processgene ontology D6RGH6|GO:0007346Inferred only

Other names

6 names

Resolves to: MCIDAS

Also called: IDASMCIMcIdas proteinMCINMulticiliate differentiation and DNA synthesis-associated cell cycle proteinProtein Idas

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