Proteins/UNIPROT:P56270

MAZ

ProteinUNIPROT:P56270

Transcriptional regulator, potentially with dual roles in transcription initiation and termination..

[Isoform 1]: Binds DNA and functions as a transcriptional activator. Binds to two G/A-rich sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors..

[Isoform 2]: Binds DNA and functions as a transcriptional activator. Inhibits MAZ isoform 1-mediated transcription..

[Isoform 3]: Binds DNA and functions as a transcriptional activator..

Function from UniProtKB (P56270), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

14 statements

14 statements · 3 reference databases · Subject: MAZ · Sources: gene ontology, Hetionet, WikiPathways

Order

CSNK2A1 interacts with MAZProteinHetionet hetionet:interacts:1457-4150Inferred only
DCC interacts with MAZProteinHetionet hetionet:interacts:1630-4150Inferred only
FOS interacts with MAZProteinHetionet hetionet:interacts:2353-4150Inferred only
JUN interacts with MAZProteinHetionet hetionet:interacts:3725-4150Inferred only
MAZ participates in 16p11 2 proximal deletion syndromePathwayWikiPathways WP4949Inferred only
MAZ participates in Sudden infant death syndrome SIDS susceptibility pathwaysPathwayWikiPathways WP706Inferred only
MAZ regulates negative regulation of apoptotic signaling pathwayBiological processgene ontology P56270|GO:2001234Inferred only
MAZ regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology P56270|GO:0000122Inferred only
MAZ regulates positive regulation of cell migrationBiological processgene ontology P56270|GO:0030335Inferred only
MAZ regulates positive regulation of cell population proliferationBiological processgene ontology P56270|GO:0008284Inferred only
MAZ regulates positive regulation of DNA-templated transcriptionBiological processgene ontology P56270|GO:0045893Inferred only
MAZ regulates positive regulation of gene expressionBiological processgene ontology P56270|GO:0010628Inferred only

Show the remaining 2

MAZ regulates positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionBiological processgene ontology P56270|GO:0051897Inferred only
MAZ regulates regulation of transcription by RNA polymerase IIBiological processgene ontology P56270|GO:0006357Inferred only

Other names

10 names

Resolves to: MAZ

Also called: MAZIPur-1Purine-binding transcription factorSAF-1Serum amyloid A-activating factor-1Transcription factor Zif87ZF87Zif87Zinc finger protein 801ZNF801

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