Proteins/UNIPROT:P20794

MAK

ProteinUNIPROT:P20794

Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells..

Function from UniProtKB (P20794), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

MAK-related retinopathy has a germline basis in MAKDiseaseGenCC HGNC:6816|MONDO:0700229Inferred only
retinitis pigmentosa has a germline basis in MAKDiseaseGenCC HGNC:6816|MONDO:0019200Inferred only
retinitis pigmentosa 62 has a germline basis in MAKDiseaseGenCC HGNC:6816|MONDO:0013611Inferred only

Statements

15 statements

15 statements · 3 reference databases · Subject: MAK · Sources: Hetionet, UniProt, WikiPathways

Order

MAK covaries with LCN8ProteinHetionet hetionet:covaries:138307-4117Inferred only
MAK interacts with ANAPC11ProteinHetionet hetionet:interacts:4117-51529Inferred only
APP interacts with MAKProteinHetionet hetionet:interacts:351-4117Inferred only
MAK interacts with FZR1ProteinHetionet hetionet:interacts:4117-51343Inferred only
MAK interacts with NDUFB7ProteinHetionet hetionet:interacts:4117-4713Inferred only
MAK interacts with PPP2CBProteinHetionet hetionet:interacts:4117-5516Inferred only
MAK interacts with SERINC1ProteinHetionet hetionet:interacts:4117-57515Inferred only
MAK interacts with SLAMF7ProteinHetionet hetionet:interacts:4117-57823Inferred only
MAK interacts with SND1ProteinHetionet hetionet:interacts:27044-4117Inferred only
MAK participates in Bardet Biedl syndromePathwayWikiPathways WP5234Inferred only
MAK participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
MAK decreases the expression of CHAC1ProteinHetionet hetionet:regulates:4117-79094Inferred only

Show the remaining 3

MAK decreases the expression of SUZ12ProteinHetionet hetionet:regulates:4117-23512Inferred only
MAK decreases the expression of ZW10ProteinHetionet hetionet:regulates:4117-9183Inferred only
MAK requires the cofactor magnesium(2+)CompoundUniProt P20794Inferred only

Reactions

2 reactions

L-seryl-[protein]+ATP(4-)O-phospho-L-seryl-[protein]+ADP(3-)+hydron
Catalysed by SGK1 or CDC7 or PLK4 or STK25 or CIT or RIOK3 or MAP2K7 or CHEK1 or BCKDK or IKBKB or CASK or AURKA and 347 more alternatives
Reaction pageLeft to right

Other names

1 name

Resolves to: MAK

Also called: Male germ cell-associated kinase

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