Proteins/UNIPROT:P43355

MAGEA1

ProteinUNIPROT:P43355

May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes..

Function from UniProtKB (P43355), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

18 statements

18 statements · 3 reference databases · Subject: MAGEA1 · Sources: gene ontology, Hetionet, WikiPathways

Order

MAGEA1 interacts with DNM1LProteinHetionet hetionet:interacts:10059-4100Inferred only
HDAC1 interacts with MAGEA1ProteinHetionet hetionet:interacts:3065-4100Inferred only
HLA-A interacts with MAGEA1ProteinHetionet hetionet:interacts:3105-4100Inferred only
HLA-B interacts with MAGEA1ProteinHetionet hetionet:interacts:3106-4100Inferred only
MAGEA1 interacts with MIEF1ProteinHetionet hetionet:interacts:4100-54471Inferred only
MAGEA1 interacts with SGK1ProteinHetionet hetionet:interacts:4100-6446Inferred only
MAGEA1 interacts with SH3GLB2ProteinHetionet hetionet:interacts:4100-56904Inferred only
MAGEA1 interacts with SNW1ProteinHetionet hetionet:interacts:22938-4100Inferred only
MAGEA1 interacts with TRIM31ProteinHetionet hetionet:interacts:11074-4100Inferred only
MAGEA1 interacts with UBCProteinHetionet hetionet:interacts:4100-7316Inferred only
MAGEA1 interacts with UQCRBProteinHetionet hetionet:interacts:4100-7381Inferred only
MAGEA1 participates in Notch signalingPathwayWikiPathways WP61Inferred only

Show the remaining 6

MAGEA1 regulates negative regulation of Notch signaling pathwayBiological processgene ontology P43355|GO:0045746Inferred only
MAGEA1 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology P43355|GO:0000122Inferred only
AK3 increases the expression of MAGEA1ProteinHetionet hetionet:regulates:50808-4100Inferred only
CTRB1 increases the expression of MAGEA1ProteinHetionet hetionet:regulates:1504-4100Inferred only
DNPEP decreases the expression of MAGEA1ProteinHetionet hetionet:regulates:23549-4100Inferred only
TIMP2 increases the expression of MAGEA1ProteinHetionet hetionet:regulates:7077-4100Inferred only

Other names

6 names

Resolves to: MAGEA1

Also called: Antigen MZ2-ECancer/testis antigen 1.1CT1.1MAGE-1 antigenMAGE1MAGE1A

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