Proteins/UNIPROT:Q96JA1

LRIG1

ProteinUNIPROT:Q96JA1

Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation..

Function from UniProtKB (Q96JA1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 3 reference databases · Subject: LRIG1 · Sources: Hetionet, Reactome, WikiPathways

Order

CBL interacts with LRIG1ProteinHetionet hetionet:interacts:26018-867Inferred only
EGFR interacts with LRIG1ProteinHetionet hetionet:interacts:1956-26018Inferred only
MET interacts with LRIG1ProteinHetionet hetionet:interacts:26018-4233Inferred only
VCP interacts with LRIG1ProteinHetionet hetionet:interacts:26018-7415Inferred only
LRIG1 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
LRIG1 participates in Developmental Cell LineagesPathwayReactome R-HSA-9734767Inferred only
LRIG1 participates in Developmental Cell Lineages of the Integumentary SystemPathwayReactome R-HSA-9734779Inferred only
LRIG1 participates in Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian SkinPathwayReactome R-HSA-9725554Inferred only
LRIG1 participates in Hair follicle development cytodifferentiation stage 3 of 3PathwayWikiPathways WP2840Inferred only
LRIG1 participates in Negative regulation of MET activityPathwayReactome R-HSA-6807004Inferred only
LRIG1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
LRIG1 participates in Signaling by EGFRPathwayReactome R-HSA-177929Inferred only

Show the remaining 4

LRIG1 participates in Signaling by METPathwayReactome R-HSA-6806834Inferred only
LRIG1 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
LASP1 decreases the expression of LRIG1ProteinHetionet hetionet:regulates:3927-26018Inferred only
SRSF2 decreases the expression of LRIG1ProteinHetionet hetionet:regulates:6427-26018Inferred only

Other names

3 names

Resolves to: LRIG1

Also called: Leucine-rich repeats and immunoglobulin-like domains protein 1LIG-1LIG1

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