Proteins/UNIPROT:Q9UPQ0

LIMCH1

ProteinUNIPROT:Q9UPQ0

Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration..

Function from UniProtKB (Q9UPQ0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 2 reference databases · Subject: LIMCH1 · Sources: gene ontology, Hetionet

Order

LIMCH1 covaries with AIPProteinHetionet hetionet:covaries:22998-9049Inferred only
LIMCH1 covaries with ASCL2ProteinHetionet hetionet:covaries:22998-430Inferred only
C11orf96 covaries with LIMCH1ProteinHetionet hetionet:covaries:22998-387763Inferred only
CYSRT1 covaries with LIMCH1ProteinHetionet hetionet:covaries:22998-375791Inferred only
LIMCH1 covaries with EHD2ProteinHetionet hetionet:covaries:22998-30846Inferred only
LIMCH1 covaries with FAM181BProteinHetionet hetionet:covaries:220382-22998Inferred only
H2BC4; H2BC6; H2BC7; H2BC8; H2BC10 covaries with LIMCH1ProteinHetionet hetionet:covaries:22998-8346Inferred only
LIMCH1 covaries with LZTR1ProteinHetionet hetionet:covaries:22998-8216Inferred only
MXD3 covaries with LIMCH1ProteinHetionet hetionet:covaries:22998-83463Inferred only
LIMCH1 covaries with NHERF2ProteinHetionet hetionet:covaries:22998-9351Inferred only
LIMCH1 covaries with OXER1ProteinHetionet hetionet:covaries:165140-22998Inferred only
LIMCH1 covaries with PHOX2AProteinHetionet hetionet:covaries:22998-401Inferred only

Show the remaining 7

LIMCH1 covaries with SLC2A11ProteinHetionet hetionet:covaries:22998-66035Inferred only
LIMCH1 covaries with VWA1ProteinHetionet hetionet:covaries:22998-64856Inferred only
TFCP2 interacts with LIMCH1ProteinHetionet hetionet:interacts:22998-7024Inferred only
LIMCH1 regulates negative regulation of cell migrationBiological processgene ontology Q9UPQ0|GO:0030336Inferred only
LIMCH1 regulates positive regulation of protein phosphorylationBiological processgene ontology Q9UPQ0|GO:0001934Inferred only
LIMCH1 regulates positive regulation of stress fiber assemblyBiological processgene ontology Q9UPQ0|GO:0051496Inferred only
LIMCH1 regulates regulation of focal adhesion assemblyBiological processgene ontology Q9UPQ0|GO:0051893Inferred only

Other names

2 names

Resolves to: LIMCH1

Also called: KIAA1102LIM and calponin homology domains-containing protein 1

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