Proteins/UNIPROT:O60294

LCMT2

ProteinUNIPROT:O60294tRNA wybutosine-synthesizing protein 4

S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway (Probable). Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (Probable)..

Function from UniProtKB (O60294), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

13 statements

13 statements · 2 reference databases · Subject: LCMT2 · Sources: Hetionet, Reactome

Order

IL4R covaries with LCMT2ProteinHetionet hetionet:covaries:3566-9836Inferred only
RIF1 covaries with LCMT2ProteinHetionet hetionet:covaries:55183-9836Inferred only
UBC interacts with LCMT2ProteinHetionet hetionet:interacts:7316-9836Inferred only
LCMT2 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
LCMT2 participates in Synthesis of wybutosine at G37 of tRNA(Phe)PathwayReactome R-HSA-6782861Inferred only
LCMT2 participates in tRNA modification in the nucleus and cytosolPathwayReactome R-HSA-6782315Inferred only
LCMT2 participates in tRNA processingPathwayReactome R-HSA-72306Inferred only
CHN1 increases the expression of LCMT2ProteinHetionet hetionet:regulates:1123-9836Inferred only
CTRB1 increases the expression of LCMT2ProteinHetionet hetionet:regulates:1504-9836Inferred only
MRPL19 increases the expression of LCMT2ProteinHetionet hetionet:regulates:9801-9836Inferred only
MYD88 decreases the expression of LCMT2ProteinHetionet hetionet:regulates:4615-9836Inferred only
NXF1 decreases the expression of LCMT2ProteinHetionet hetionet:regulates:10482-9836Inferred only

Show the remaining 1

SNX6 increases the expression of LCMT2ProteinHetionet hetionet:regulates:58533-9836Inferred only

Reactions

2 reactions

7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe)+S-adenosyl-L-methionine7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe)+S-adenosyl-L-homocysteine
Catalysed by LCMT2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:36903CC BY 4.0Reference data
7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe)+S-adenosyl-L-methionine+carbon dioxidewybutosine(37) in tRNA(Phe)+S-adenosyl-L-homocysteine+2hydron
Catalysed by

Other names

6 names

Resolves to: LCMT2

Also called: KIAA0547Leucine carboxyl methyltransferase 2tRNA yW-synthesizing protein 4tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferasetRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferaseTYW4

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