Proteins/UNIPROT:Q96JM7

L3MBTL3

ProteinUNIPROT:Q96JM7

Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation. Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins. Required for normal maturation of myeloid progenitor cells (By similarity)..

Function from UniProtKB (Q96JM7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 2 reference databases · Subject: L3MBTL3 · Sources: gene ontology, Hetionet

Order

GPR101 covaries with L3MBTL3ProteinHetionet hetionet:covaries:83550-84456Inferred only
CTNNB1 interacts with L3MBTL3ProteinHetionet hetionet:interacts:1499-84456Inferred only
L3MBTL3 interacts with LRRK2ProteinHetionet hetionet:interacts:120892-84456Inferred only
LZTR1 interacts with L3MBTL3ProteinHetionet hetionet:interacts:8216-84456Inferred only
UBC interacts with L3MBTL3ProteinHetionet hetionet:interacts:7316-84456Inferred only
L3MBTL3 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q96JM7|GO:0045892Inferred only
L3MBTL3 regulates negative regulation of transcription initiation-coupled chromatin remodelingBiological processgene ontology Q96JM7|GO:0160217Inferred only
L3MBTL3 regulates positive regulation of ubiquitin-dependent protein catabolic processBiological processgene ontology Q96JM7|GO:2000060Inferred only

Other names

7 names

Resolves to: L3MBTL3

Also called: 3H-l(3)mbt-like protein 3KIAA1798L(3)mbt-like protein 3L3mbt-like 3MBT-1MBT1

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