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Proteins/UNIPROT:P03952

KLKB1

Protein·UNIPROT:P03952

Open in the graph

Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

Function from UniProtKB (P03952), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

inherited prekallikrein deficiency has a germline basis in KLKB1DiseaseGenCC HGNC:6371|MONDO:0012901Inferred only

Statements

33 statements

33 statements · 4 reference databases · Subject: KLKB1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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KLKB1 covaries with AADACL2ProteinHetionet hetionet:covaries:344752-3818Inferred only
KLKB1 covaries with IFIT1BProteinHetionet hetionet:covaries:3818-439996Inferred only
VWDE covaries with KLKB1ProteinHetionet hetionet:covaries:221806-3818Inferred only
F12 interacts with KLKB1ProteinHetionet hetionet:interacts:2161-3818Inferred only
HGF interacts with KLKB1ProteinHetionet hetionet:interacts:3082-3818Inferred only
HGFAC interacts with KLKB1ProteinHetionet hetionet:interacts:3083-3818Inferred only
IGFBP3 interacts with KLKB1ProteinHetionet hetionet:interacts:3486-3818Inferred only
KLKB1 interacts with KNG1ProteinHetionet hetionet:interacts:3818-3827Inferred only
KLKB1 interacts with MST1ProteinHetionet hetionet:interacts:3818-4485Inferred only
KLKB1 interacts with SERPINA5ProteinHetionet hetionet:interacts:3818-5104Inferred only
KLKB1 participates in Activation of Matrix MetalloproteinasesPathwayReactome R-HSA-1592389Inferred only
KLKB1 participates in Blood clotting cascadePathwayWikiPathways WP272Inferred only

Show the remaining 21

KLKB1 participates in Coagulation pathwayPathwayReactome R-HSA-9769740Inferred only
KLKB1 participates in Complement and coagulation cascadesPathwayWikiPathways WP558Inferred only
KLKB1 participates in Complement systemPathwayWikiPathways WP2806Inferred only
KLKB1 participates in Defective factor XII causes hereditary angioedemaPathwayReactome R-HSA-9657688Inferred only
KLKB1 participates in Defective SERPING1 causes hereditary angioedemaPathwayReactome R-HSA-9657689Inferred only
KLKB1 participates in Defects of contact activation system and kallikrein-kinin systemPathwayReactome R-HSA-9946127Inferred only
KLKB1 participates in Degradation of the extracellular matrixPathwayReactome R-HSA-1474228Inferred only
KLKB1 participates in Dengue 2 interactions with complement and coagulation cascadesPathwayWikiPathways WP3896Inferred only
KLKB1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
KLKB1 participates in Diseases of Immune SystemPathwayReactome R-HSA-5260271Inferred only
KLKB1 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
KLKB1 participates in FXIIa activates plasma kallikrein-kinin systemPathwayReactome R-HSA-9970672Inferred only
KLKB1 participates in FXIIa, PKa-dependent activation of coagulation pathwayPathwayReactome R-HSA-9935598Inferred only
KLKB1 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
KLKB1 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
KLKB1 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
KLKB1 participates in Kinin Kallikrein pathwayPathwayWikiPathways WP5089Inferred only
KLKB1 participates in Regulation of clotting cascadePathwayReactome R-HSA-9769739Inferred only
KLKB1 participates in Regulation of FXIIa and plasma kallikrein activityPathwayReactome R-HSA-9855719Inferred only
KLKB1 participates in Renin Angiotensin System and Bradykinin pathways in COVID 19PathwayWikiPathways WP4969Inferred only
KLKB1 regulates positive regulation of fibrinolysisBiological processgene ontology P03952|GO:0051919Inferred only

Other names

6 names

Resolves to: KLKB1

Also called: [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain]Fletcher factorKininogeninKLK3PKKPlasma prekallikrein

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