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Proteins/UNIPROT:Q9UEF7
Exhibits beta-glucuronidase activity in vitro despite lacking canonical catalytic Glu residues of glycosyl hydrolase 1 family enzymes (By similarity). Hydrolyzes steroid beta-D-glucuronides including estradiol-3-beta-D-glucuronide, estrone-3-beta-D-glucuronide and estriol-3-beta-D-glucuronide (By similarity). Essential for the interaction between FGF23 and FGFR1 and for FGF23-mediated regulation of renal vitamin D and phosphate homeostasis (By similarity)..
The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling..
Function from UniProtKB (Q9UEF7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
9 statements
9 statements · 5 reference databases · Subject: KL · Sources: Bgee, gene ontology, Hetionet, Rhea, WikiPathways
11 reactions
MAM01924e+waterMAM01923e+MAM01973e+proton
Catalysed by KL
Reaction pageReversibleBalancedEC 3.2.1.31extracellular space
Human-GEM MAR03162CC BY 4.0Reference data
MAM01321e+waterMAM00766e+MAM01973e+proton
Catalysed by KL
Reaction pageReversibleBalancedEC 3.2.1.31extracellular space
1 name
Resolves to: KL
MAM01924c+waterMAM01923c+MAM01973c+proton
Catalysed by KL
Reaction pageReversibleBalancedEC 3.2.1.31cytosol
Human-GEM MAR06492CC BY 4.0Reference data
MAM01321c+waterMAM00766c+MAM01973c+proton
Catalysed by KL
Reaction pageLeft to rightBalancedEC 3.2.1.31cytosol
Human-GEM MAR06496CC BY 4.0Reference data
water+MAM02079lMAM01973l+MAM02056l
Reaction pageLeft to rightBalancedEC 3.2.1.31lysosome
Human-GEM MAR07235CC BY 4.0Reference data
MAM01520l+waterMAM01521l+MAM01973l
Reaction pageLeft to rightBalancedEC 3.2.1.31lysosome
Human-GEM MAR07505CC BY 4.0Reference data
MAM01535l+waterMAM01536l+MAM01973l
Reaction pageLeft to rightBalancedEC 3.2.1.31lysosome
Human-GEM MAR07529CC BY 4.0Reference data
MAM01546l+waterMAM01547l+MAM01973l
Reaction pageLeft to rightBalancedEC 3.2.1.31lysosome
Human-GEM MAR07546CC BY 4.0Reference data
MAM01557l+waterMAM01558l+MAM01973l
Reaction pageLeft to rightBalancedEC 3.2.1.31lysosome
Human-GEM MAR07562CC BY 4.0Reference data
water+MAM02141lMAM01973l+MAM02140l
Reaction pageLeft to rightBalancedEC 3.2.1.31lysosome
Human-GEM MAR07571CC BY 4.0Reference data
a beta-D-glucuronoside+waterD-glucuronate+an alcohol
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:17633CC BY 4.0Reference data