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Proteins/UNIPROT:Q9Y6Y0
Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors. Inhibits pre-mRNA splicing (in vitro). May play a role in mRNA nuclear export..
(Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein. The BTB and Kelch domains are required for splicing activity. Promotes export of viral M mRNA and RNP via its interaction with mRNA export factor ALYREF..
Function from UniProtKB (Q9Y6Y0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
16 statements
16 statements · 2 reference databases · Subject: IVNS1ABP · Sources: gene ontology, Hetionet
10 names
Resolves to: IVNS1ABP