Proteins/UNIPROT:Q9H1B7

IRF2BPL

ProteinUNIPROT:Q9H1B7

Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins. Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway. Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity)..

Function from UniProtKB (Q9H1B7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

neurodegenerative disease has a germline basis in IRF2BPLDiseaseGenCC HGNC:14282|MONDO:0005559Inferred only
neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures has a germline basis in IRF2BPLDiseaseGenCC HGNC:14282|MONDO:0060759Inferred only

Statements

9 statements

9 statements · 3 reference databases · Subject: IRF2BPL · Sources: gene ontology, Hetionet, WikiPathways

Order

NR2F6 covaries with IRF2BPLProteinHetionet hetionet:covaries:2063-64207Inferred only
HCK interacts with IRF2BPLProteinHetionet hetionet:interacts:3055-64207Inferred only
NPM3 interacts with IRF2BPLProteinHetionet hetionet:interacts:10360-64207Inferred only
SUMO2 interacts with IRF2BPLProteinHetionet hetionet:interacts:64207-6613Inferred only
UBC interacts with IRF2BPLProteinHetionet hetionet:interacts:64207-7316Inferred only
UBE2Q1 interacts with IRF2BPLProteinHetionet hetionet:interacts:55585-64207Inferred only
IRF2BPL participates in T cell activation SARS CoV 2PathwayWikiPathways WP5098Inferred only
IRF2BPL regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q9H1B7|GO:0000122Inferred only
IRF2BPL regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q9H1B7|GO:0045944Inferred only

Other names

5 names

Resolves to: IRF2BPL

Also called: C14orf4EAP1Enhanced at puberty protein 1Interferon regulatory factor 2-binding protein-likeKIAA1865

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