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Proteins/UNIPROT:Q9UHD0

IL19

Protein·UNIPROT:Q9UHD0

Open in the graph

Cytokine that functions as an anti-inflammatory and proangiogenic factor. Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13. Produced by osteocytes, stimulates granulopoiesis and neutrophil formation (By similarity). Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB. In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3..

Function from UniProtKB (Q9UHD0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

12 statements

12 statements · 4 reference databases · Subject: IL19 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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PNPLA7 covaries with IL19ProteinHetionet hetionet:covaries:29949-375775Inferred only
IL19 interacts with IL20RAProteinHetionet hetionet:interacts:29949-53832Inferred only
IL19 interacts with IL20RBProteinHetionet hetionet:interacts:29949-53833Inferred only
RUNX1T1 interacts with IL19ProteinHetionet hetionet:interacts:29949-862Inferred only
IL19 participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
IL19 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
IL19 participates in IL19 signalingPathwayWikiPathways WP5422Inferred only
IL19 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
IL19 participates in Interleukin-20 family signalingPathwayReactome R-HSA-8854691Inferred only
IL19 participates in Overview of proinflammatory and profibrotic mediatorsPathwayWikiPathways WP5095Inferred only
IL19 participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
IL19 regulates negative regulation of low-density lipoprotein particle clearanceBiological processgene ontology Q9UHD0|GO:0010989Inferred only

Other names

4 names

Resolves to: IL19

Also called: IL-19Melanoma differentiation-associated protein-like proteinNG.1ZMDA1

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