Proteins/UNIPROT:Q14773

ICAM4

ProteinUNIPROT:Q14773

Functions as a receptor ligand for the monocyte/macrophage-specific ITGAX:ITGB2 integrin complex and mediates erythrophagocytosis. Receptor ligand of the platelet-specific ITGA2B:ITGB3 integrin complex involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets. In vitro, is also a receptor ligand of multiple integrin receptors complexes such ITGAL:ITGB2, ITGAM:ITGB2, ITGA5:ITGB1, ITGA5:ITGB3 and ITGA5:ITGB5 integrin complexes..

Function from UniProtKB (Q14773), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

10 statements

10 statements · 2 reference databases · Subject: ICAM4 · Sources: Hetionet, Reactome

Order

ICAM4 interacts with ITGA4ProteinHetionet hetionet:interacts:3386-3676Inferred only
ICAM4 interacts with ITGAMProteinHetionet hetionet:interacts:3386-3684Inferred only
ICAM4 interacts with ITGAVProteinHetionet hetionet:interacts:3386-3685Inferred only
ICAM4 interacts with ITGB2ProteinHetionet hetionet:interacts:3386-3689Inferred only
ICAM4 interacts with RHAGProteinHetionet hetionet:interacts:3386-6005Inferred only
ICAM4 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
ICAM4 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
ICAM4 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
ICAM4 participates in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellPathwayReactome R-HSA-198933Inferred only
ICAM4 participates in Integrin cell surface interactionsPathwayReactome R-HSA-216083Inferred only

Other names

5 names

Resolves to: ICAM4

Also called: CD antigen CD242ICAM-4Landsteiner-Wiener blood group glycoproteinLWLW blood group protein

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