Proteins/UNIPROT:Q9Y2N7

HIF3A

ProteinUNIPROT:Q9Y2N7

Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression. Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity)..

[Isoform 2]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Also inhibits hypoxia-inducible ARNT-mediated gene expression..

[Isoform 3]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation..

[Isoform 4]: Attenuates the ability of transcription factor HIF1A and EPAS1/HIF2A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. May act as a tumor suppressor and inhibits malignant cell transformation..

[Isoform 5]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation..

Function from UniProtKB (Q9Y2N7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

19 statements

19 statements · 4 reference databases · Subject: HIF3A · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

OR2D3 covaries with HIF3AProteinHetionet hetionet:covaries:120775-64344Inferred only
PARG covaries with HIF3AProteinHetionet hetionet:covaries:64344-8505Inferred only
HIF3A covaries with TMEM59LProteinHetionet hetionet:covaries:25789-64344Inferred only
ARNT interacts with HIF3AProteinHetionet hetionet:interacts:405-64344Inferred only
EGLN1 interacts with HIF3AProteinHetionet hetionet:interacts:54583-64344Inferred only
HIF3A interacts with EGLN3ProteinHetionet hetionet:interacts:112399-64344Inferred only
ELOC interacts with HIF3AProteinHetionet hetionet:interacts:64344-6921Inferred only
HIF1A interacts with HIF3AProteinHetionet hetionet:interacts:3091-64344Inferred only
HIF3A participates in Cellular response to hypoxiaPathwayReactome R-HSA-1234174Inferred only
HIF3A participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
HIF3A participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
HIF3A participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only

Show the remaining 7

HIF3A participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
HIF3A participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
HIF3A participates in NeddylationPathwayReactome R-HSA-8951664Inferred only
HIF3A participates in Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaPathwayReactome R-HSA-1234176Inferred only
HIF3A participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
HIF3A participates in Transcriptional regulation of pluripotent stem cellsPathwayReactome R-HSA-452723Inferred only
HIF3A regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q9Y2N7|GO:0006357Inferred only

Other names

12 names

Resolves to: HIF3A

Also called: Basic-helix-loop-helix-PAS protein MOP7BHLHE17Class E basic helix-loop-helix protein 17HIF-3-alphaHIF3-alphaHIF3-alpha-1Inhibitory PAS domain proteinIPASMember of PAS protein 7MOP7PAS domain-containing protein 7PASD7

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