Proteins/UNIPROT:Q8NG08

HELB

ProteinUNIPROT:Q8NG08

5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB. As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation. Acts independently of TP53BP1. Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress..

Function from UniProtKB (Q8NG08), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

6 statements

6 statements · 2 reference databases · Subject: HELB · Sources: gene ontology, Hetionet

Order

POLA1 interacts with HELBProteinHetionet hetionet:interacts:5422-92797Inferred only
POLA2 interacts with HELBProteinHetionet hetionet:interacts:23649-92797Inferred only
RPA1 interacts with HELBProteinHetionet hetionet:interacts:6117-92797Inferred only
UBC interacts with HELBProteinHetionet hetionet:interacts:7316-92797Inferred only
HELB regulates negative regulation of double-strand break repair via homologous recombinationBiological processgene ontology Q8NG08|GO:2000042Inferred only
HELB regulates regulation of DNA double-strand break processingBiological processgene ontology Q8NG08|GO:1903775Inferred only

Reactions

1 reaction

ATP(4-)+waterADP(3-)+hydrogenphosphate+hydron
Catalysed by HFM1 or SMCHD1 or FIGNL2 or DDX39A or DDX3X or CHD1 or CHD2 or TOR1A or TOR1B or DDX3Y or DHX15 or GET3 and 193 more alternatives

Other names

2 names

Resolves to: HELB

Also called: DNA 5'-3' helicase BhDHB

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