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Proteins/UNIPROT:O43614
G protein-coupled receptor that binds neuropeptides orexin-A and orexin-B, two neuropeptides derived from a common precursor, prepro-orexin. Upon neuropeptide ligand binding, HCRTR2 can couple with both G(q)/11 and G(i)/o heterotrimeric G proteins thereby initiating distinct downstream signaling cascades. Involved in regulating the sleep-wake cycle (By similarity). Contributes to central regulation of glucose homeostasis (By similarity)..
Function from UniProtKB (O43614), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
17 statements
17 statements · 4 reference databases · Subject: HCRTR2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
6 names
Resolves to: HCRTR2