Proteins/UNIPROT:O43612

HCRT

ProteinUNIPROT:O43612

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested..

[Orexin-A]: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity)..

[Orexin-B]: Binds to orexin receptor HCRTR2/OX2R only (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity)..

Function from UniProtKB (O43612), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

21 statements

21 statements · 4 reference databases · Subject: HCRT · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

OR1L6 covaries with HCRTProteinHetionet hetionet:covaries:3060-392390Inferred only
HCRT interacts with HCRTR1ProteinHetionet hetionet:interacts:3060-3061Inferred only
HCRT interacts with HCRTR2ProteinHetionet hetionet:interacts:3060-3062Inferred only
HCRT interacts with NPFFR2ProteinHetionet hetionet:interacts:10886-3060Inferred only
HCRT participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
HCRT participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only
HCRT participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
HCRT participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
HCRT participates in Orexin and neuropeptides FF and QRFP bind to their respective receptorsPathwayReactome R-HSA-389397Inferred only
HCRT participates in Orexin receptor pathwayPathwayWikiPathways WP5094Inferred only
HCRT participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
HCRT participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only

Show the remaining 9

HCRT participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
HCRT regulates negative regulation of DNA replicationBiological processgene ontology O43612|GO:0008156Inferred only
HCRT regulates negative regulation of potassium ion transportBiological processgene ontology O43612|GO:0043267Inferred only
HCRT regulates negative regulation of transmission of nerve impulseBiological processgene ontology O43612|GO:0051970Inferred only
HCRT regulates positive regulation of calcium ion transportBiological processgene ontology O43612|GO:0051928Inferred only
HCRT regulates positive regulation of cold-induced thermogenesisBiological processgene ontology O43612|GO:0120162Inferred only
HCRT regulates positive regulation of cytosolic calcium ion concentrationBiological processgene ontology O43612|GO:0007204Inferred only
HCRT regulates positive regulation of transmission of nerve impulseBiological processgene ontology O43612|GO:0051971Inferred only
HCRT regulates regulation of neurotransmitter secretionBiological processgene ontology O43612|GO:0046928Inferred only

Other names

12 names

Resolves to: HCRT

Also called: ]Hcrt1Hcrt2HypocretinHypocretin-1Hypocretin-2Orexin precursorOXPPORXPPOXPrepro-orexinPreprohypocretin

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