Proteins/UNIPROT:P22492

H1-6

ProteinUNIPROT:P22492

Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable)..

Function from UniProtKB (P22492), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

13 statements

13 statements · 2 reference databases · Subject: H1-6 · Sources: gene ontology, Hetionet

Order

H1-6 covaries with ADAMTS7ProteinHetionet hetionet:covaries:11173-3010Inferred only
H1-6 covaries with DCAF16ProteinHetionet hetionet:covaries:3010-54876Inferred only
HEY2 covaries with H1-6ProteinHetionet hetionet:covaries:23493-3010Inferred only
H1-6 covaries with MISPProteinHetionet hetionet:covaries:126353-3010Inferred only
OR1I1 covaries with H1-6ProteinHetionet hetionet:covaries:126370-3010Inferred only
OR2A2 covaries with H1-6ProteinHetionet hetionet:covaries:3010-442361Inferred only
RNF39 covaries with H1-6ProteinHetionet hetionet:covaries:3010-80352Inferred only
H1-6 interacts with IRAK4ProteinHetionet hetionet:interacts:3010-51135Inferred only
H1-6 interacts with PRKCAProteinHetionet hetionet:interacts:3010-5578Inferred only
H1-6 interacts with SUMO1ProteinHetionet hetionet:interacts:3010-7341Inferred only
H1-6 interacts with UBCProteinHetionet hetionet:interacts:3010-7316Inferred only
H1-6 regulates negative regulation of DNA recombinationBiological processgene ontology P22492|GO:0045910Inferred only

Show the remaining 1

H1-6 increases the expression of SERPINA3ProteinHetionet hetionet:regulates:3010-12Inferred only

Other names

5 names

Resolves to: H1-6

Also called: H1FTH1THIST1H1THistone H1tTesticular H1 histone

← Every protein Find it in the graph →