Loading the page.
Proteins/UNIPROT:Q8TAA5
[Isoform 1]: Nucleotide exchange factor (NEF) for mitochondrial HSP70 (mt-HSP70/HSPA9), facilitating the release of ADP from HSPA9 to allow ATP rebinding, which is essential for the chaperone cycle. Functions as a component of the presequence translocase-associated motor (PAM) complex, which drives ATP-dependent import of proteins into the mitochondrial matrix. In the PAM complex, supports the HSPA9-driven pulling mechanism that translocates polypeptides through the TIM23 complex. Functions as a redox-regulated component of the mitochondrial protein import and folding machinery, with its activity modulated by oxidative stress. May control the nucleotide-dependent binding of HSPA9 to substrate proteins (By similarity)..
[Isoform 2]: NERCLIN functions as a negative regulator of cardiolipin homeostasis and mitochondrial ultrastructure, contributing to the stress-induced adaptation of mitochondrial dynamics. Responds to heat stress by ensuring OPA1 processing and cell survival. Lacks nucleotide exchange factor (NEF) activity. This isoform is specifically expressed in human and some non-human primates..
Function from UniProtKB (Q8TAA5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
20 statements
20 statements · 4 reference databases · Subject: GRPEL2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
2 names
Resolves to: GRPEL2