Proteins/UNIPROT:Q14416

GRM2

ProteinUNIPROT:Q14416

Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate. Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling (By similarity). Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization..

(Microbial infection) Plays an important role in influenza virus internalization..

(Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of GRM2 to enter cells..

(Microbial infection) Acts as a host entry factor for SARS-CoV-2 that hijacks the endocytosis of GRM2 to enter cells..

Function from UniProtKB (Q14416), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

26 statements

26 statements · 4 reference databases · Subject: GRM2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

GRM2 covaries with DEFB1ProteinHetionet hetionet:covaries:1672-2912Inferred only
GRM2 covaries with EPHB2ProteinHetionet hetionet:covaries:2048-2912Inferred only
GRM2 covaries with GATA1ProteinHetionet hetionet:covaries:2623-2912Inferred only
NUDT14 covaries with GRM2ProteinHetionet hetionet:covaries:256281-2912Inferred only
GRM2 covaries with PTNProteinHetionet hetionet:covaries:2912-5764Inferred only
VSTM2B covaries with GRM2ProteinHetionet hetionet:covaries:2912-342865Inferred only
GRM2 covaries with ZYXProteinHetionet hetionet:covaries:2912-7791Inferred only
GNA15 interacts with GRM2ProteinHetionet hetionet:interacts:2769-2912Inferred only
GNAQ interacts with GRM2ProteinHetionet hetionet:interacts:2776-2912Inferred only
GRM2 interacts with RGS12ProteinHetionet hetionet:interacts:2912-6002Inferred only
GRM2 interacts with TAMALINProteinHetionet hetionet:interacts:160622-2912Inferred only
GRM2 participates in Class C/3 (Metabotropic glutamate/pheromone receptors)PathwayReactome R-HSA-420499Inferred only

Show the remaining 14

GRM2 participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
GRM2 participates in GABA and glutamate signalling in epileptogenesisPathwayWikiPathways WP5600Inferred only
GRM2 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
GRM2 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
GRM2 participates in GPCRs class C metabotropic glutamate pheromonePathwayWikiPathways WP501Inferred only
GRM2 participates in Neuroinflammation and glutamatergic signalingPathwayWikiPathways WP5083Inferred only
GRM2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
GRM2 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
GRM2 regulates negative regulation of adenylate cyclase activityBiological processgene ontology Q14416|GO:0007194Inferred only
GRM2 regulates positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionBiological processgene ontology Q14416|GO:0051897Inferred only
GRM2 regulates regulation of dopamine secretionBiological processgene ontology Q14416|GO:0014059Inferred only
GRM2 regulates regulation of glutamate secretionBiological processgene ontology Q14416|GO:0014048Inferred only
GRM2 regulates regulation of response to drugBiological processgene ontology Q14416|GO:2001023Inferred only
GRM2 regulates regulation of synaptic transmission, glutamatergicBiological processgene ontology Q14416|GO:0051966Inferred only

Other names

3 names

Resolves to: GRM2

Also called: GPRC1BMetabotropic glutamate receptor 2MGLUR2

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