Proteins/UNIPROT:P13224

GP1BB

ProteinUNIPROT:P13224

Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium.

Function from UniProtKB (P13224), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

autosomal dominant macrothrombocytopenia has a germline basis in GP1BBDiseaseGenCC HGNC:4440|MONDO:0015372Inferred only
Bernard-Soulier syndrome has a germline basis in GP1BBDiseaseGenCC HGNC:4440|MONDO:0009276Inferred only

Statements

25 statements

25 statements · 4 reference databases · Subject: GP1BB · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

GP1BB interacts with GP9ProteinHetionet hetionet:interacts:2812-2815Inferred only
GP1BB interacts with NCF1ProteinHetionet hetionet:interacts:2812-653361Inferred only
GP1BB interacts with PRKACAProteinHetionet hetionet:interacts:2812-5566Inferred only
GP1BB interacts with TGFB1I1ProteinHetionet hetionet:interacts:2812-7041Inferred only
GP1BB interacts with TRAF4ProteinHetionet hetionet:interacts:2812-9618Inferred only
GP1BB interacts with YWHAZProteinHetionet hetionet:interacts:2812-7534Inferred only
GP1BB participates in 22q11 2 copy number variation syndromePathwayWikiPathways WP4657Inferred only
GP1BB participates in Amplification and propagation of coagulation cascadePathwayReactome R-HSA-9769743Inferred only
GP1BB participates in Coagulation pathwayPathwayReactome R-HSA-9769740Inferred only
GP1BB participates in Defective binding of VWF variant to GPIb:IX:VPathwayReactome R-HSA-9846298Inferred only
GP1BB participates in Defective F9 activationPathwayReactome R-HSA-9673221Inferred only
GP1BB participates in Defective factor IX causes hemophilia BPathwayReactome R-HSA-9668250Inferred only

Show the remaining 13

GP1BB participates in Defects of Coagulation cascadePathwayReactome R-HSA-9769726Inferred only
GP1BB participates in Defects of platelet adhesion to exposed collagenPathwayReactome R-HSA-9823587Inferred only
GP1BB participates in DiseasePathwayReactome R-HSA-1643685Inferred only
GP1BB participates in Diseases of hemostasisPathwayReactome R-HSA-9671793Inferred only
GP1BB participates in Enhanced binding of GP1BA variant to VWF multimer:collagenPathwayReactome R-HSA-9845620Inferred only
GP1BB participates in FXIIa, PKa-dependent activation of coagulation pathwayPathwayReactome R-HSA-9935598Inferred only
GP1BB participates in GP1b-IX-V activation signallingPathwayReactome R-HSA-430116Inferred only
GP1BB participates in HemostasisPathwayReactome R-HSA-109582Inferred only
GP1BB participates in Platelet activation, signaling and aggregationPathwayReactome R-HSA-76002Inferred only
GP1BB participates in Platelet Adhesion to exposed collagenPathwayReactome R-HSA-75892Inferred only
GP1BB participates in Platelet Aggregation (Plug Formation)PathwayReactome R-HSA-76009Inferred only
GP1BB participates in Regulation of clotting cascadePathwayReactome R-HSA-9769739Inferred only
GP1BB regulates positive regulation of platelet activationBiological processgene ontology P13224|GO:0010572Inferred only

Other names

5 names

Resolves to: GP1BB

Also called: Antigen CD42b-betaCD antigen CD42cGP-Ib betaGPIb-betaGPIbB

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