Proteins/UNIPROT:Q3T8J9

GON4L

ProteinUNIPROT:Q3T8J9

Acts as a key transcription regulator of histones. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with GON4L and MIZF. Together with CRAMP1, binds to the promoters of H1 genes (H1-2, H1-3, H1-4, H1-5 and H1-10/H1x), driving their transcription. Also acts as a transcription corepressor, as part of a complex with YY1, SIN3A and HDAC1 (By similarity). Required for B-cell lymphopoiesis (By similarity)..

Function from UniProtKB (Q3T8J9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

complex neurodevelopmental disorder has a germline basis in GON4LDiseaseGenCC HGNC:25973|MONDO:0100038Inferred only

Statements

6 statements

6 statements · 2 reference databases · Subject: GON4L · Sources: gene ontology, Hetionet

Order

TDRD10 covaries with GON4LProteinHetionet hetionet:covaries:126668-54856Inferred only
ZMYM5 covaries with GON4LProteinHetionet hetionet:covaries:54856-9205Inferred only
ITGB5 interacts with GON4LProteinHetionet hetionet:interacts:3693-54856Inferred only
SUMO2 interacts with GON4LProteinHetionet hetionet:interacts:54856-6613Inferred only
UBC interacts with GON4LProteinHetionet hetionet:interacts:54856-7316Inferred only
GON4L regulates regulation of DNA-templated transcriptionBiological processgene ontology Q3T8J9|GO:0006355Inferred only

Other names

5 names

Resolves to: GON4L

Also called: GON-4 homologGON4KIAA1606YARPYin Yang 1-associated-related protein

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