Proteins/UNIPROT:P43220

GLP1R

ProteinUNIPROT:P43220

G protein-coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1 (By similarity)..

Function from UniProtKB (P43220), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

22 statements

22 statements · 4 reference databases · Subject: GLP1R · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ZYX covaries with GLP1RProteinHetionet hetionet:covaries:2740-7791Inferred only
ARRB1 interacts with GLP1RProteinHetionet hetionet:interacts:2740-408Inferred only
GCG interacts with GLP1RProteinHetionet hetionet:interacts:2641-2740Inferred only
GLP1R interacts with SUMO1ProteinHetionet hetionet:interacts:2740-7341Inferred only
GLP1R interacts with UBCProteinHetionet hetionet:interacts:2740-7316Inferred only
GLP1R participates in Class B/2 (Secretin family receptors)PathwayReactome R-HSA-373080Inferred only
GLP1R participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
GLP1R participates in GLP 1 from intestine and pancreas and role in glucose homeostasisPathwayWikiPathways WP5452Inferred only
GLP1R participates in GLP 1 in pancreatic islet cellsPathwayWikiPathways WP5447Inferred only
GLP1R participates in Glucagon-like Peptide-1 (GLP1) regulates insulin secretionPathwayReactome R-HSA-381676Inferred only
GLP1R participates in Glucagon-type ligand receptorsPathwayReactome R-HSA-420092Inferred only
GLP1R participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only

Show the remaining 10

GLP1R participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
GLP1R participates in GPCRs class B secretin likePathwayWikiPathways WP334Inferred only
GLP1R participates in Integration of energy metabolismPathwayReactome R-HSA-163685Inferred only
GLP1R participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
GLP1R participates in Regulation of insulin secretionPathwayReactome R-HSA-422356Inferred only
GLP1R participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
GLP1R participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
GLP1R regulates positive regulation of blood pressureBiological processgene ontology P43220|GO:0045777Inferred only
GLP1R regulates positive regulation of cytosolic calcium ion concentrationBiological processgene ontology P43220|GO:0007204Inferred only
GLP1R regulates regulation of heart contractionBiological processgene ontology P43220|GO:0008016Inferred only

Other names

3 names

Resolves to: GLP1R

Also called: GLP-1 receptorGLP-1-RGLP-1R

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