Proteins/UNIPROT:Q9NWU2

GID8

ProteinUNIPROT:Q9NWU2

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation..

Function from UniProtKB (Q9NWU2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

29 statements

29 statements · 4 reference databases · Subject: GID8 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CAMSAP1 covaries with GID8ProteinHetionet hetionet:covaries:157922-54994Inferred only
CHCHD10 covaries with GID8ProteinHetionet hetionet:covaries:400916-54994Inferred only
GID8 covaries with CIRBPProteinHetionet hetionet:covaries:1153-54994Inferred only
GID8 covaries with MOB3AProteinHetionet hetionet:covaries:126308-54994Inferred only
OTOP3 covaries with GID8ProteinHetionet hetionet:covaries:347741-54994Inferred only
RHOA covaries with GID8ProteinHetionet hetionet:covaries:387-54994Inferred only
GID8 covaries with TALDO1ProteinHetionet hetionet:covaries:54994-6888Inferred only
TIGD2 covaries with GID8ProteinHetionet hetionet:covaries:166815-54994Inferred only
GID8 covaries with UBTD1ProteinHetionet hetionet:covaries:54994-80019Inferred only
YTHDF1 covaries with GID8ProteinHetionet hetionet:covaries:54915-54994Inferred only
ARMC8 interacts with GID8ProteinHetionet hetionet:interacts:25852-54994Inferred only
MAEA interacts with GID8ProteinHetionet hetionet:interacts:10296-54994Inferred only

Show the remaining 17

MKLN1 interacts with GID8ProteinHetionet hetionet:interacts:4289-54994Inferred only
RANBP9 interacts with GID8ProteinHetionet hetionet:interacts:10048-54994Inferred only
GID8 interacts with RMND5AProteinHetionet hetionet:interacts:54994-64795Inferred only
UBC interacts with GID8ProteinHetionet hetionet:interacts:54994-7316Inferred only
GID8 participates in Aerobic respiration and respiratory electron transportPathwayReactome R-HSA-1428517Inferred only
GID8 participates in Ciliary landscapePathwayWikiPathways WP4352Inferred only
GID8 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
GID8 participates in Pyruvate metabolismPathwayReactome R-HSA-70268Inferred only
GID8 participates in Regulation of pyruvate metabolismPathwayReactome R-HSA-9861718Inferred only
GID8 regulates positive regulation of canonical Wnt signaling pathwayBiological processgene ontology Q9NWU2|GO:0090263Inferred only
GID8 regulates positive regulation of cell population proliferationBiological processgene ontology Q9NWU2|GO:0008284Inferred only
CTRB2 increases the expression of GID8ProteinHetionet hetionet:regulates:440387-54994Inferred only
GPSM1 increases the expression of GID8ProteinHetionet hetionet:regulates:26086-54994Inferred only
HSPA5 decreases the expression of GID8ProteinHetionet hetionet:regulates:3309-54994Inferred only
NT5E decreases the expression of GID8ProteinHetionet hetionet:regulates:4907-54994Inferred only
PKIG increases the expression of GID8ProteinHetionet hetionet:regulates:11142-54994Inferred only
VCP decreases the expression of GID8ProteinHetionet hetionet:regulates:7415-54994Inferred only

Other names

3 names

Resolves to: GID8

Also called: C20orf11TWA1Two hybrid-associated protein 1 with RanBPM

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