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Proteins/UNIPROT:Q02643

GHRHR

Protein·UNIPROT:Q02643

Open in the graph

Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

Function from UniProtKB (Q02643), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

isolated growth hormone deficiency type IB has a germline basis in GHRHRDiseaseGenCC HGNC:4266|MONDO:0013006Inferred only
isolated growth hormone deficiency, type 4 has a germline basis in GHRHRDiseaseGenCC HGNC:4266|MONDO:0032567Inferred only

Statements

26 statements

26 statements · 4 reference databases · Subject: GHRHR · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

BRI3 covaries with GHRHRProteinHetionet hetionet:covaries:25798-2692Inferred only
KLLN covaries with GHRHRProteinHetionet hetionet:covaries:100144748-2692Inferred only
GHRHR covaries with OR6S1ProteinHetionet hetionet:covaries:2692-341799Inferred only
GHRHR covaries with PCDHB15ProteinHetionet hetionet:covaries:2692-56121Inferred only
GHRHR covaries with RRP7AProteinHetionet hetionet:covaries:2692-27341Inferred only
GHRHR covaries with SCARF2ProteinHetionet hetionet:covaries:2692-91179Inferred only
GHRHR covaries with SPINDOCProteinHetionet hetionet:covaries:144097-2692Inferred only
GHRHR covaries with TMEM59LProteinHetionet hetionet:covaries:25789-2692Inferred only
GHRHR covaries with ZNF296ProteinHetionet hetionet:covaries:162979-2692Inferred only
GHRH interacts with GHRHRProteinHetionet hetionet:interacts:2691-2692Inferred only
GHRHR interacts with GHRLProteinHetionet hetionet:interacts:2692-51738Inferred only
GHRHR interacts with MLNRProteinHetionet hetionet:interacts:2692-2862Inferred only

Show the remaining 14

GHRHR participates in Class B/2 (Secretin family receptors)PathwayReactome R-HSA-373080Inferred only
GHRHR participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
GHRHR participates in Glucagon-type ligand receptorsPathwayReactome R-HSA-420092Inferred only
GHRHR participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
GHRHR participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
GHRHR participates in GPCRs class B secretin likePathwayWikiPathways WP334Inferred only
GHRHR participates in GPCRs otherPathwayWikiPathways WP117Inferred only
GHRHR participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
GHRHR participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
GHRHR regulates positive regulation of cell population proliferationBiological processgene ontology Q02643|GO:0008284Inferred only
GHRHR regulates positive regulation of circadian sleep/wake cycle, non-REM sleepBiological processgene ontology Q02643|GO:0046010Inferred only
GHRHR regulates positive regulation of growth hormone secretionBiological processgene ontology Q02643|GO:0060124Inferred only
GHRHR regulates positive regulation of insulin-like growth factor receptor signaling pathwayBiological processgene ontology Q02643|GO:0043568Inferred only
GHRHR regulates positive regulation of multicellular organism growthBiological processgene ontology Q02643|GO:0040018Inferred only

Other names

4 names

Resolves to: GHRHR

Also called: GHRH receptorGRF receptorGRFRGrowth hormone-releasing factor receptor

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