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Proteins/UNIPROT:P01241

GH1

Protein·UNIPROT:P01241

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Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Function from UniProtKB (P01241), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

4 rows

isolated growth hormone deficiency type IA has a germline basis in GH1DiseaseGenCC HGNC:4261|MONDO:0009876Inferred only
isolated growth hormone deficiency type IB has a germline basis in GH1DiseaseGenCC HGNC:4261|MONDO:0013006Inferred only
isolated growth hormone deficiency type II has a germline basis in GH1DiseaseGenCC HGNC:4261|MONDO:0008250Inferred only
short stature due to growth hormone qualitative anomaly has a germline basis in GH1DiseaseGenCC HGNC:4261|MONDO:0009879Inferred only

Statements

23 statements

23 statements · 4 reference databases · Subject: GH1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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GH1 interacts with GHRProteinHetionet hetionet:interacts:2688-2690Inferred only
GH1 interacts with PRLRProteinHetionet hetionet:interacts:2688-5618Inferred only
GH1 participates in AdipogenesisPathwayWikiPathways WP236Inferred only
GH1 participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
GH1 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
GH1 participates in Endochondral ossificationPathwayWikiPathways WP474Inferred only
GH1 participates in Endochondral ossification with skeletal dysplasiasPathwayWikiPathways WP4808Inferred only
GH1 participates in Growth hormone receptor signalingPathwayReactome R-HSA-982772Inferred only
GH1 participates in Hormonal control of pubertal growth spurtPathwayWikiPathways WP4194Inferred only
GH1 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
GH1 participates in JAK STAT signaling in the regulation of beta cellsPathwayWikiPathways WP5358Inferred only
GH1 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only

Show the remaining 11

GH1 participates in Orexin receptor pathwayPathwayWikiPathways WP5094Inferred only
GH1 participates in Peptide hormone metabolismPathwayReactome R-HSA-2980736Inferred only
GH1 participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
GH1 participates in Prolactin receptor signalingPathwayReactome R-HSA-1170546Inferred only
GH1 participates in Synthesis, secretion, and deacylation of GhrelinPathwayReactome R-HSA-422085Inferred only
GH1 regulates positive regulation of D-glucose transmembrane transportBiological processgene ontology P01241|GO:0010828Inferred only
GH1 regulates positive regulation of insulin-like growth factor receptor signaling pathwayBiological processgene ontology P01241|GO:0043568Inferred only
GH1 regulates positive regulation of MAPK cascadeBiological processgene ontology P01241|GO:0043410Inferred only
GH1 regulates positive regulation of multicellular organism growthBiological processgene ontology P01241|GO:0040018Inferred only
GH1 regulates positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionBiological processgene ontology P01241|GO:0051897Inferred only
GH1 regulates positive regulation of receptor signaling pathway via JAK-STATBiological processgene ontology P01241|GO:0046427Inferred only

Other names

5 names

Resolves to: GH1

Also called: GHGH-NGrowth hormoneGrowth hormone 1Pituitary growth hormone

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