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Proteins/UNIPROT:Q14397

GCKR

Protein·UNIPROT:Q14397

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Regulates glucokinase (GCK) by forming an inactive complex with this enzyme. Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity..

Function from UniProtKB (Q14397), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

20 statements

20 statements · 4 reference databases · Subject: GCKR · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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CDKN1A interacts with GCKRProteinHetionet hetionet:interacts:1026-2646Inferred only
GCK interacts with GCKRProteinHetionet hetionet:interacts:2645-2646Inferred only
GCKR interacts with TRAF2ProteinHetionet hetionet:interacts:2646-7186Inferred only
GCKR interacts with UBCProteinHetionet hetionet:interacts:2646-7316Inferred only
GCKR participates in Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)PathwayReactome R-HSA-5619107Inferred only
GCKR participates in DiseasePathwayReactome R-HSA-1643685Inferred only
GCKR participates in Disorders of transmembrane transportersPathwayReactome R-HSA-5619115Inferred only
GCKR participates in Familial hyperlipidemia type 4PathwayWikiPathways WP5111Inferred only
GCKR participates in Glucose metabolismPathwayReactome R-HSA-70326Inferred only
GCKR participates in GlycolysisPathwayReactome R-HSA-70171Inferred only
GCKR participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
GCKR participates in Metabolism of carbohydrates and carbohydrate derivativesPathwayReactome R-HSA-71387Inferred only

Show the remaining 8

GCKR participates in Regulation of Glucokinase by Glucokinase Regulatory ProteinPathwayReactome R-HSA-170822Inferred only
GCKR participates in SLC transporter disordersPathwayReactome R-HSA-5619102Inferred only
GCKR participates in Wnt signaling NetPathPathwayWikiPathways WP363Inferred only
GCKR regulates negative regulation of glucokinase activityBiological processgene ontology Q14397|GO:0033132Inferred only
GCKR regulates regulation of glycolytic processBiological processgene ontology Q14397|GO:0006110Inferred only
GCKR increases the expression of ADRB2ProteinHetionet hetionet:regulates:2646-154Inferred only
GCKR decreases the expression of RPS4Y1ProteinHetionet hetionet:regulates:2646-6192Inferred only
GCKR decreases the expression of TYMSProteinHetionet hetionet:regulates:2646-7298Inferred only

Other names

2 names

Resolves to: GCKR

Also called: GKRPGlucokinase regulator

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