Proteins/UNIPROT:Q9UJT9

FBXL7

ProteinUNIPROT:Q9UJT9

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest (By similarity). It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5..

Function from UniProtKB (Q9UJT9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

20 statements

20 statements · 3 reference databases · Subject: FBXL7 · Sources: gene ontology, Hetionet, Reactome

Order

FBXL7 covaries with ACKR5ProteinHetionet hetionet:covaries:11318-23194Inferred only
FBXL7 covaries with DDX51ProteinHetionet hetionet:covaries:23194-317781Inferred only
OR5B2 covaries with FBXL7ProteinHetionet hetionet:covaries:23194-390190Inferred only
FBXL7 covaries with PCSK9ProteinHetionet hetionet:covaries:23194-255738Inferred only
FBXL7 covaries with RPS15ProteinHetionet hetionet:covaries:23194-6209Inferred only
APP interacts with FBXL7ProteinHetionet hetionet:interacts:23194-351Inferred only
SKP1 interacts with FBXL7ProteinHetionet hetionet:interacts:23194-6500Inferred only
FBXL7 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
FBXL7 participates in Antigen processing: Ubiquitination & Proteasome degradationPathwayReactome R-HSA-983168Inferred only
FBXL7 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
FBXL7 participates in Cell Cycle, MitoticPathwayReactome R-HSA-69278Inferred only
FBXL7 participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only

Show the remaining 8

FBXL7 participates in FBXL7 down-regulates AURKA during mitotic entry and in early mitosisPathwayReactome R-HSA-8854050Inferred only
FBXL7 participates in G2/M TransitionPathwayReactome R-HSA-69275Inferred only
FBXL7 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
FBXL7 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
FBXL7 participates in Mitotic G2-G2/M phasesPathwayReactome R-HSA-453274Inferred only
FBXL7 participates in NeddylationPathwayReactome R-HSA-8951664Inferred only
FBXL7 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
FBXL7 regulates regulation of apoptotic processBiological processgene ontology Q9UJT9|GO:0042981Inferred only

Other names

5 names

Resolves to: FBXL7

Also called: F-box and leucine-rich repeat protein 7F-box protein FBL6/FBL7FBL6FBL7KIAA0840

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