ACKR5

Atypical chemokine receptor that regulates chemokine levels and localization through chemokine binding, independently of activating classical ligand-induced signaling pathways such as G protein activation and Ca(2+) mobilization. Instead, it mediates chemokine sequestration, transport, or internalization to control their availability. Acts as a scavenger for a broad range of chemokines from CXC, CC and XC chemokine ligand families including CXCL9, CXCL10, CXCL12, CXCL13, CXCL11, CXCL14, CCL1, CCL11, CCL19, CCL25, CCL28 and XCL1. Is the only atypical receptor for chemokines CXCL13 and CCL28. Has a strong constitutive association with beta-arrestins, which is essential for intracellular receptor trafficking and chemokine scavenging, and occurs independently of ligand binding. Cooperates with ACKR3 and ACKR4 in regulating serum levels of CXCL12 and CCL19, respectively. Acts as an important modulator of cellular immunity (By similarity)..

Function from UniProtKB (O15218), read 2026-09-23. CC BY 4.0.