Proteins/UNIPROT:Q8N5H3

FAM89B

ProteinUNIPROT:Q8N5H3

Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation..

Function from UniProtKB (Q8N5H3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

17 statements

17 statements · 2 reference databases · Subject: FAM89B · Sources: gene ontology, Hetionet

Order

BTBD17 covaries with FAM89BProteinHetionet hetionet:covaries:23625-388419Inferred only
SNX18 covaries with FAM89BProteinHetionet hetionet:covaries:112574-23625Inferred only
TMEM151A covaries with FAM89BProteinHetionet hetionet:covaries:23625-256472Inferred only
TMEM178B covaries with FAM89BProteinHetionet hetionet:covaries:100507421-23625Inferred only
FAM89B regulates negative regulation of SMAD protein signal transductionBiological processgene ontology Q8N5H3|GO:0060392Inferred only
FAM89B regulates negative regulation of transforming growth factor beta receptor signaling pathwayBiological processgene ontology Q8N5H3|GO:0030512Inferred only
FAM89B regulates positive regulation of cell migrationBiological processgene ontology Q8N5H3|GO:0030335Inferred only
ABCB6 decreases the expression of FAM89BProteinHetionet hetionet:regulates:10058-23625Inferred only
CDKN1A decreases the expression of FAM89BProteinHetionet hetionet:regulates:1026-23625Inferred only
CEP43 increases the expression of FAM89BProteinHetionet hetionet:regulates:11116-23625Inferred only
CRAT decreases the expression of FAM89BProteinHetionet hetionet:regulates:1384-23625Inferred only
CTRB1 decreases the expression of FAM89BProteinHetionet hetionet:regulates:1504-23625Inferred only

Show the remaining 5

DLD increases the expression of FAM89BProteinHetionet hetionet:regulates:1738-23625Inferred only
IQGAP1 increases the expression of FAM89BProteinHetionet hetionet:regulates:8826-23625Inferred only
KCNN4 decreases the expression of FAM89BProteinHetionet hetionet:regulates:3783-23625Inferred only
PMF1 increases the expression of FAM89BProteinHetionet hetionet:regulates:11243-23625Inferred only
PMM2 decreases the expression of FAM89BProteinHetionet hetionet:regulates:5373-23625Inferred only

Other names

2 names

Resolves to: FAM89B

Also called: Leucine repeat adapter protein 25Lrap25

← Every protein Find it in the graph →