Proteins/UNIPROT:Q9H790

EXO5

ProteinUNIPROT:Q9H790

Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity..

Function from UniProtKB (Q9H790), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

5 statements

5 statements · 2 reference databases · Subject: EXO5 · Sources: Hetionet, UniProt

Order

MUC20 covaries with EXO5ProteinHetionet hetionet:covaries:200958-64789Inferred only
RPA1 interacts with EXO5ProteinHetionet hetionet:interacts:6117-64789Inferred only
UBC interacts with EXO5ProteinHetionet hetionet:interacts:64789-7316Inferred only
EXO5 requires the cofactor magnesium(2+)CompoundUniProt Q9H790Inferred only
EXO5 requires the cofactor tetra-mu3-sulfido-tetraironCompoundUniProt Q9H790Inferred only

Other names

5 names

Resolves to: EXO5

Also called: C1orf176Defects in morphology protein 1 homologDEM1Exo VhExo5

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