Proteins/UNIPROT:O95936

EOMES

ProteinUNIPROT:O95936

Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Required for differentiation and migration of unipolar dendritic brush cells. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes..

Function from UniProtKB (O95936), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

microcephaly-polymicrogyria-corpus callosum agenesis syndrome has a germline basis in EOMESDiseaseGenCC HGNC:3372|MONDO:0015745Inferred only

Statements

24 statements

24 statements · 4 reference databases · Subject: EOMES · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

LRRC14 covaries with EOMESProteinHetionet hetionet:covaries:8320-9684Inferred only
OR52A1 covaries with EOMESProteinHetionet hetionet:covaries:23538-8320Inferred only
EOMES covaries with PTMSProteinHetionet hetionet:covaries:5763-8320Inferred only
EOMES covaries with TGFB1ProteinHetionet hetionet:covaries:7040-8320Inferred only
VGF covaries with EOMESProteinHetionet hetionet:covaries:7425-8320Inferred only
VPS37D covaries with EOMESProteinHetionet hetionet:covaries:155382-8320Inferred only
EOMES covaries with ZNF25ProteinHetionet hetionet:covaries:219749-8320Inferred only
ZNF502 covaries with EOMESProteinHetionet hetionet:covaries:8320-91392Inferred only
PFDN1 interacts with EOMESProteinHetionet hetionet:interacts:5201-8320Inferred only
EOMES participates in CardiogenesisPathwayReactome R-HSA-9733709Inferred only
EOMES participates in Development and heterogeneity of the ILC familyPathwayWikiPathways WP3893Inferred only
EOMES participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only

Show the remaining 12

EOMES participates in Endoderm differentiationPathwayWikiPathways WP2853Inferred only
EOMES participates in Epithelial-Mesenchymal Transition (EMT) during gastrulationPathwayReactome R-HSA-9758919Inferred only
EOMES participates in Formation of definitive endodermPathwayReactome R-HSA-9823730Inferred only
EOMES participates in GastrulationPathwayReactome R-HSA-9758941Inferred only
EOMES participates in Germ layer formation at gastrulationPathwayReactome R-HSA-9754189Inferred only
EOMES participates in Mesodermal commitment pathwayPathwayWikiPathways WP2857Inferred only
EOMES participates in ReproductionPathwayReactome R-HSA-1474165Inferred only
EOMES participates in Specification of primordial germ cellsPathwayReactome R-HSA-9827857Inferred only
EOMES regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology O95936|GO:0000122Inferred only
EOMES regulates positive regulation of DNA-templated transcriptionBiological processgene ontology O95936|GO:0045893Inferred only
EOMES regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology O95936|GO:0045944Inferred only
EOMES regulates regulation of transcription by RNA polymerase IIBiological processgene ontology O95936|GO:0006357Inferred only

Other names

4 names

Resolves to: EOMES

Also called: T-box brain protein 2T-brain-2TBR-2TBR2

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