Proteins/UNIPROT:Q96EB1

ELP4

ProteinUNIPROT:Q96EB1

Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs..

Function from UniProtKB (Q96EB1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

aniridia 2 has a germline basis in ELP4DiseaseGenCC HGNC:1171|MONDO:0014937Inferred only
ocular dysgenesis caused by defects in PAX6 regulation has a germline basis in ELP4DiseaseGenCC HGNC:1171|MONDO:0700246Inferred only

Statements

19 statements

19 statements · 4 reference databases · Subject: ELP4 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

TCEAL4 covaries with ELP4ProteinHetionet hetionet:covaries:26610-79921Inferred only
ELP5 interacts with ELP4ProteinHetionet hetionet:interacts:23587-26610Inferred only
HINFP interacts with ELP4ProteinHetionet hetionet:interacts:25988-26610Inferred only
ELP4 interacts with MMS19ProteinHetionet hetionet:interacts:26610-64210Inferred only
PPP1CC interacts with ELP4ProteinHetionet hetionet:interacts:26610-5501Inferred only
SRP68 interacts with ELP4ProteinHetionet hetionet:interacts:26610-6730Inferred only
UBC interacts with ELP4ProteinHetionet hetionet:interacts:26610-7316Inferred only
ELP4 participates in Chromatin modifying enzymesPathwayReactome R-HSA-3247509Inferred only
ELP4 participates in Chromatin organizationPathwayReactome R-HSA-4839726Inferred only
ELP4 participates in Endoderm differentiationPathwayWikiPathways WP2853Inferred only
ELP4 participates in HATs acetylate histonesPathwayReactome R-HSA-3214847Inferred only
ELP4 participates in Mesodermal commitment pathwayPathwayWikiPathways WP2857Inferred only

Show the remaining 7

ELP4 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q96EB1|GO:0006357Inferred only
ELP4 regulates regulation of translationBiological processgene ontology Q96EB1|GO:0006417Inferred only
CRADD decreases the expression of ELP4ProteinHetionet hetionet:regulates:8738-26610Inferred only
GBP2 increases the expression of ELP4ProteinHetionet hetionet:regulates:2634-26610Inferred only
OXCT1 increases the expression of ELP4ProteinHetionet hetionet:regulates:5019-26610Inferred only
PIGB decreases the expression of ELP4ProteinHetionet hetionet:regulates:9488-26610Inferred only
ZBTB20 increases the expression of ELP4ProteinHetionet hetionet:regulates:26137-26610Inferred only

Other names

4 names

Resolves to: ELP4

Also called: C11orf19hELP4PAX6 neighbor gene proteinPAXNEB

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