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Proteins/UNIPROT:Q1HG44

DUOXA2

Protein·UNIPROT:Q1HG44

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Required for the maturation and transport of functional DUOX2 from the endoplasmic reticulum to the plasma membrane. Recruits DUOX2 to the apical cell membrane..

Function from UniProtKB (Q1HG44), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

familial thyroid dyshormonogenesis has a germline basis in DUOXA2DiseaseGenCC HGNC:32698|MONDO:0010132Inferred only
thyroid dyshormonogenesis 5 has a germline basis in DUOXA2DiseaseGenCC HGNC:32698|MONDO:0010137Inferred only

Statements

9 statements

9 statements · 4 reference databases · Subject: DUOXA2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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NEB covaries with DUOXA2ProteinHetionet hetionet:covaries:405753-4703Inferred only
DUOXA2 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
DUOXA2 participates in Metabolism of amine-derived hormonesPathwayReactome R-HSA-209776Inferred only
DUOXA2 participates in Metabolism of amino acids and derivativesPathwayReactome R-HSA-71291Inferred only
DUOXA2 participates in Thyroid hormones production and peripheral downstream signaling effectsPathwayWikiPathways WP4746Inferred only
DUOXA2 participates in Thyroxine biosynthesisPathwayReactome R-HSA-209968Inferred only
DUOXA2 regulates positive regulation of cell motilityBiological processgene ontology Q1HG44|GO:2000147Inferred only
DUOXA2 regulates positive regulation of hydrogen peroxide biosynthetic processBiological processgene ontology Q1HG44|GO:0010729Inferred only
DUOXA2 regulates regulation of thyroid hormone generationBiological processgene ontology Q1HG44|GO:2000609Inferred only

Other names

2 names

Resolves to: DUOXA2

Also called: Dual oxidase activator 2Dual oxidase maturation factor 2

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