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Proteins/UNIPROT:Q7L8W6

DPH6

Protein·UNIPROT:Q7L8W6Diphthine--ammonia ligase

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Amidase that may catalyze the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity)..

Function from UniProtKB (Q7L8W6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

6 statements

6 statements · 2 reference databases · Subject: DPH6 · Sources: Hetionet, Reactome

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CENPE covaries with DPH6ProteinHetionet hetionet:covaries:1062-89978Inferred only
UBC interacts with DPH6ProteinHetionet hetionet:interacts:7316-89978Inferred only
DPH6 participates in Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activationPathwayReactome R-HSA-163841Inferred only
DPH6 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
DPH6 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
DPH6 participates in Synthesis of diphthamide-EEF2PathwayReactome R-HSA-5358493Inferred only

Reactions

1 reaction

diphthine-[translation elongation factor 2]+ammonium+ATP(4-)diphthamide-[translation elongation factor 2]+AMP+diphosphate(3-)+hydron
Catalysed by DPH6
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:19753CC BY 4.0Reference data

Other names

6 names

Resolves to: DPH6

Also called: ATP-binding domain-containing protein 4ATPBD4Diphthamide synthaseDiphthamide synthetaseDPH6 homologProtein DPH6 homolog

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