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Proteins/UNIPROT:Q9BZG8
Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Acts as a tumor suppressor..
Function from UniProtKB (Q9BZG8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
18 statements
18 statements · 5 reference databases · Subject: DPH1 · Sources: Bgee, Hetionet, Reactome, Rhea, UniProt
1 reaction
L-histidyl-[translation elongation factor 2]+S-adenosyl-L-methionine2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2]+S-methyl-5'-thioadenosine+hydron
Catalysed by DPH1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:36783CC BY 4.0Reference data
8 names
Resolves to: DPH1