Proteins/UNIPROT:Q8WXU2

DNAAF4

ProteinUNIPROT:Q8WXU2

Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity..

Function from UniProtKB (Q8WXU2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

primary ciliary dyskinesia has a germline basis in DNAAF4DiseaseGenCC HGNC:21493|MONDO:0016575Inferred only
primary ciliary dyskinesia 25 has a germline basis in DNAAF4DiseaseGenCC HGNC:21493|MONDO:0014203Inferred only

Statements

13 statements

13 statements · 3 reference databases · Subject: DNAAF4 · Sources: gene ontology, Hetionet, WikiPathways

Order

DNAAF4 covaries with CENPFProteinHetionet hetionet:covaries:1063-161582Inferred only
DNAAF4 covaries with SHC4ProteinHetionet hetionet:covaries:161582-399694Inferred only
GABARAP interacts with DNAAF4ProteinHetionet hetionet:interacts:11337-161582Inferred only
GABARAPL1 interacts with DNAAF4ProteinHetionet hetionet:interacts:161582-23710Inferred only
GABARAPL2 interacts with DNAAF4ProteinHetionet hetionet:interacts:11345-161582Inferred only
HSPA1A interacts with DNAAF4ProteinHetionet hetionet:interacts:161582-3303Inferred only
HSPA1A interacts with DNAAF4ProteinHetionet hetionet:interacts:161582-3304Inferred only
MAP1LC3B interacts with DNAAF4ProteinHetionet hetionet:interacts:161582-81631Inferred only
DNAAF4 interacts with MAP1LC3CProteinHetionet hetionet:interacts:161582-440738Inferred only
STUB1 interacts with DNAAF4ProteinHetionet hetionet:interacts:10273-161582Inferred only
DNAAF4 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
DNAAF4 regulates regulation of intracellular estrogen receptor signaling pathwayBiological processgene ontology Q8WXU2|GO:0033146Inferred only

Show the remaining 1

DNAAF4 regulates regulation of proteasomal protein catabolic processBiological processgene ontology Q8WXU2|GO:0061136Inferred only

Other names

4 names

Resolves to: DNAAF4

Also called: Dynein axonemal assembly factor 4Dyslexia susceptibility 1 candidate gene 1 proteinDYX1C1EKN1

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