Proteins/UNIPROT:Q8NFW5

DMBX1

ProteinUNIPROT:Q8NFW5

Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development (By similarity)..

Function from UniProtKB (Q8NFW5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

complex neurodevelopmental disorder has a germline basis in DMBX1DiseaseGenCC HGNC:19026|MONDO:0100038Inferred only

Statements

11 statements

11 statements · 3 reference databases · Subject: DMBX1 · Sources: gene ontology, Hetionet, WikiPathways

Order

CHRM3 covaries with DMBX1ProteinHetionet hetionet:covaries:1131-127343Inferred only
GRIN1 covaries with DMBX1ProteinHetionet hetionet:covaries:127343-2902Inferred only
KCNC4 covaries with DMBX1ProteinHetionet hetionet:covaries:127343-3749Inferred only
OR2AT4 covaries with DMBX1ProteinHetionet hetionet:covaries:127343-341152Inferred only
OR52A5 covaries with DMBX1ProteinHetionet hetionet:covaries:127343-390054Inferred only
DMBX1 covaries with SESN2ProteinHetionet hetionet:covaries:127343-83667Inferred only
OTX2 interacts with DMBX1ProteinHetionet hetionet:interacts:127343-5015Inferred only
UBC interacts with DMBX1ProteinHetionet hetionet:interacts:127343-7316Inferred only
DMBX1 participates in Neural crest differentiationPathwayWikiPathways WP2064Inferred only
DMBX1 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q8NFW5|GO:0045892Inferred only
DMBX1 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q8NFW5|GO:0006357Inferred only

Other names

5 names

Resolves to: DMBX1

Also called: MBXOrthodenticle homolog 3OTX3Paired-like homeobox protein DMBX1PAXB

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