Proteins/UNIPROT:Q6IQ26

DENND5A

ProteinUNIPROT:Q6IQ26

Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity)..

Function from UniProtKB (Q6IQ26), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

developmental and epileptic encephalopathy, 49 has a germline basis in DENND5ADiseaseGenCC HGNC:19344|MONDO:0015002Inferred only

Statements

14 statements

14 statements · 3 reference databases · Subject: DENND5A · Sources: gene ontology, Hetionet, Reactome

Order

TMEM121 covaries with DENND5AProteinHetionet hetionet:covaries:23258-80757Inferred only
AR interacts with DENND5AProteinHetionet hetionet:interacts:23258-367Inferred only
CSNK2B interacts with DENND5AProteinHetionet hetionet:interacts:1460-23258Inferred only
PRKCZ interacts with DENND5AProteinHetionet hetionet:interacts:23258-5590Inferred only
UBC interacts with DENND5AProteinHetionet hetionet:interacts:23258-7316Inferred only
DENND5A participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
DENND5A participates in RAB GEFs exchange GTP for GDP on RABsPathwayReactome R-HSA-8876198Inferred only
DENND5A participates in Rab regulation of traffickingPathwayReactome R-HSA-9007101Inferred only
DENND5A participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
DENND5A regulates negative regulation of neuron projection developmentBiological processgene ontology Q6IQ26|GO:0010977Inferred only
EBP decreases the expression of DENND5AProteinHetionet hetionet:regulates:10682-23258Inferred only
FGFR2 decreases the expression of DENND5AProteinHetionet hetionet:regulates:2263-23258Inferred only

Show the remaining 2

ILK decreases the expression of DENND5AProteinHetionet hetionet:regulates:3611-23258Inferred only
ZFAND6 decreases the expression of DENND5AProteinHetionet hetionet:regulates:54469-23258Inferred only

Other names

3 names

Resolves to: DENND5A

Also called: KIAA1091Rab6-interacting protein 1RAB6IP1

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