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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q9Y271

CYSLTR1

Protein·UNIPROT:Q9Y271

Open in the graph

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

Function from UniProtKB (Q9Y271), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

26 statements

26 statements · 4 reference databases · Subject: CYSLTR1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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CYSLTR1 covaries with FAM171A2ProteinHetionet hetionet:covaries:10800-284069Inferred only
CYSLTR1 covaries with HDAC5ProteinHetionet hetionet:covaries:10014-10800Inferred only
EGR1 interacts with CYSLTR1ProteinHetionet hetionet:interacts:10800-1958Inferred only
CYSLTR1 participates in Anti-inflammatory response favouring Leishmania parasite infectionPathwayReactome R-HSA-9662851Inferred only
CYSLTR1 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
CYSLTR1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
CYSLTR1 participates in Eicosanoid ligand-binding receptorsPathwayReactome R-HSA-391903Inferred only
CYSLTR1 participates in Eicosanoid metabolism via lipooxygenases LOX PathwayWikiPathways WP4721Inferred only
CYSLTR1 participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only
CYSLTR1 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
CYSLTR1 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
CYSLTR1 participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only

Show the remaining 14

CYSLTR1 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
CYSLTR1 participates in Leishmania infectionPathwayReactome R-HSA-9658195Inferred only
CYSLTR1 participates in Leishmania parasite growth and survivalPathwayReactome R-HSA-9664433Inferred only
CYSLTR1 participates in Leukotriene receptorsPathwayReactome R-HSA-391906Inferred only
CYSLTR1 participates in LTC4-CYSLTR mediated IL4 productionPathwayReactome R-HSA-9664535Inferred only
CYSLTR1 participates in Omega 6 fatty acids in senescencePathwayWikiPathways WP5424Inferred only
CYSLTR1 participates in Parasitic Infection PathwaysPathwayReactome R-HSA-9824443Inferred only
CYSLTR1 participates in Potential therapeutics for SARSPathwayReactome R-HSA-9679191Inferred only
CYSLTR1 participates in Prostaglandin and leukotriene metabolism in senescence PathwayWikiPathways WP5122Inferred only
CYSLTR1 participates in SARS-CoV InfectionsPathwayReactome R-HSA-9679506Inferred only
CYSLTR1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CYSLTR1 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
CYSLTR1 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
CYSLTR1 regulates positive regulation of cytosolic calcium ion concentrationBiological processgene ontology Q9Y271|GO:0007204Inferred only

Other names

5 names

Resolves to: CYSLTR1

Also called: CYSLT1Cysteinyl leukotriene D4 receptorG protein-coupled receptor HG55HMTMF81LTD4 receptor

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