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Proteins/UNIPROT:P13385
GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by TMEM8A modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm..
Function from UniProtKB (P13385), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
26 statements
26 statements · 3 reference databases · Subject: CRIPTO · Sources: gene ontology, Hetionet, Reactome
7 names
Resolves to: CRIPTO