Proteins/UNIPROT:P24387

CRHBP

ProteinUNIPROT:P24387

Specifically binds and inactivates the corticotropin-releasing hormone (CRH) and urocortin-1 (UCN) hormones, thereby inhibiting the hypothalamus-pituitary-adrenal axis and preventing corticotropin hormone (ACTH) production. May be required to prevent inappropriate pituitary-adrenal stimulation in pregnancy..

Function from UniProtKB (P24387), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

15 statements

15 statements · 4 reference databases · Subject: CRHBP · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CRHBP covaries with EHD4ProteinHetionet hetionet:covaries:1393-30844Inferred only
CRHBP covaries with HMCN1ProteinHetionet hetionet:covaries:1393-83872Inferred only
CRHBP covaries with HOXC13ProteinHetionet hetionet:covaries:1393-3229Inferred only
SLC6A14 covaries with CRHBPProteinHetionet hetionet:covaries:11254-1393Inferred only
XTBD1 covaries with CRHBPProteinHetionet hetionet:covaries:1393-91368Inferred only
CRHBP interacts with UCNProteinHetionet hetionet:interacts:1393-7349Inferred only
CRHBP participates in Class B/2 (Secretin family receptors)PathwayReactome R-HSA-373080Inferred only
CRHBP participates in Corticotropin releasing hormone signalingPathwayWikiPathways WP2355Inferred only
CRHBP participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
CRHBP participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CRHBP participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
CRHBP regulates negative regulation of corticotropin secretionBiological processgene ontology P24387|GO:0051460Inferred only

Show the remaining 3

CRHBP regulates regulation of cellular response to stressBiological processgene ontology P24387|GO:0080135Inferred only
CRHBP regulates regulation of corticotropin secretionBiological processgene ontology P24387|GO:0051459Inferred only
CRHBP regulates regulation of NMDA receptor activityBiological processgene ontology P24387|GO:2000310Inferred only

Other names

5 names

Resolves to: CRHBP

Also called: Corticotropin-releasing factor-binding proteinCRF-binding proteinCRF-BPCRFBPCRH-BP

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