Proteins/UNIPROT:O00230

CORT

ProteinUNIPROT:O00230

Precursor of neuropeptides that bind to all somatostatin receptor (SSTR) subtypes. Inhibits cAMP production induced by forskolin through SSTRs..

[Cortistatin-14]: Neuropeptide with neuronal depressant and sleep-modulating properties (By similarity). Acts as a ligand for MRGPRX2 receptor in mast cells..

Function from UniProtKB (O00230), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

15 statements

15 statements · 3 reference databases · Subject: CORT · Sources: gene ontology, Hetionet, Reactome

Order

CORT interacts with GHSRProteinHetionet hetionet:interacts:1325-2693Inferred only
CORT interacts with MRGPRX2ProteinHetionet hetionet:interacts:117194-1325Inferred only
CORT interacts with SSTR1ProteinHetionet hetionet:interacts:1325-6751Inferred only
CORT interacts with SSTR2ProteinHetionet hetionet:interacts:1325-6752Inferred only
CORT interacts with SSTR3ProteinHetionet hetionet:interacts:1325-6753Inferred only
CORT interacts with SSTR4ProteinHetionet hetionet:interacts:1325-6754Inferred only
CORT interacts with SSTR5ProteinHetionet hetionet:interacts:1325-6755Inferred only
CORT participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
CORT participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
CORT participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
CORT participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
CORT participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only

Show the remaining 3

CORT participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
CORT participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
CORT regulates regulation of cell migrationBiological processgene ontology O00230|GO:0030334Inferred only

Other names

1 name

Resolves to: CORT

Also called: Cortistatin [Cleaved into: Cortistatin-29; Cortistatin-17; Cortistatin-14]

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