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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q5HYK3

COQ5

Protein·UNIPROT:Q5HYK32-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Open in the graph

Methyltransferase required for the conversion of 2-decaprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)..

Function from UniProtKB (Q5HYK3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

mitochondrial disease has a germline basis in COQ5DiseaseGenCC HGNC:28722|MONDO:0044970Inferred only

Statements

10 statements

10 statements · 6 reference databases · Subject: COQ5 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways

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COQ5 is expressed in hindlimb stylopod muscleAnatomyBgee ENSG00000110871Inferred only
UBC interacts with COQ5ProteinHetionet hetionet:interacts:7316-84274Inferred only
COQ5 participates in Disorders of mitochondrial homeostatis dynamics protein import and quality controlPathwayWikiPathways WP5504Inferred only
COQ5 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
COQ5 participates in Metabolism of cofactorsPathwayReactome R-HSA-8978934Inferred only
COQ5 participates in Metabolism of vitamins and cofactorsPathwayReactome R-HSA-196854Inferred only
COQ5 participates in Ubiquinol biosynthesisPathwayReactome R-HSA-2142789Inferred only
2-methoxy-6-(all-trans-decaprenyl)benzene-1,4-diol is a substrate of COQ5CompoundHuman-GEM MAR06908Inferred only
2-methoxy-6-(all-trans-decaprenyl)benzene-1,4-diol is a substrate of COQ5CompoundRhea RHEA:44764Inferred only
5-methoxy-2-methyl-3-(all-trans-decaprenyl)benzene-1,4-diol is a substrate of COQ5CompoundRhea RHEA:44764Inferred only

Reactions

2 reactions

2-methoxy-6-(all-trans-decaprenyl)benzene-1,4-diol+S-adenosyl-L-methionine5-methoxy-2-methyl-3-(all-trans-decaprenyl)benzene-1,4-diol+proton+CHEBI:16680
Catalysed by COQ5
Reaction pageLeft to rightBalancedEC 2.1.1.201mitochondrial matrix
Human-GEM MAR06908CC BY 4.0Reference data
2-methoxy-6-(all-trans-decaprenyl)benzene-1,4-diol+S-adenosyl-L-methionine5-methoxy-2-methyl-3-(all-trans-decaprenyl)benzene-1,4-diol+S-adenosyl-L-homocysteine

Other names

1 name

Resolves to: COQ5

Also called: Ubiquinone biosynthesis methyltransferase COQ5

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Catalysed by COQ5

Reaction pageDirection not assertedBalanced

Rhea RHEA:44764CC BY 4.0Reference data