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Proteins/UNIPROT:Q8IYT2
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs..
Function from UniProtKB (Q8IYT2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 statements
5 statements · 2 reference databases · Subject: CMTR2 · Sources: Hetionet, WikiPathways
1 reaction
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA+S-adenosyl-L-methioninea 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA+S-adenosyl-L-homocysteine+hydron
Catalysed by CMTR2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:67024CC BY 4.0Reference data
10 names
Resolves to: CMTR2