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Proteins/UNIPROT:Q8N1G2
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway..
Function from UniProtKB (Q8N1G2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
46 statements
46 statements · 4 reference databases · Subject: CMTR1 · Sources: Bgee, Hetionet, Human Protein Atlas, WikiPathways
2 reactions
proton+MAM02437c+CHEBI:16680MAM02438c+S-adenosyl-L-methionine
Catalysed by CMTR1
Reaction pageReversibleBalance undeterminableEC 2.1.1.57cytosol
Human-GEM MAR09510CC BY 4.0Reference data
a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA+S-adenosyl-L-methioninea 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA+S-adenosyl-L-homocysteine+hydron
Catalysed by
10 names
Resolves to: CMTR1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:67020CC BY 4.0Reference data