Proteins/UNIPROT:P51793

CLCN4

ProteinUNIPROT:P51793

Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters..

Function from UniProtKB (P51793), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

intellectual disability, X-linked 49 has a germline basis in CLCN4DiseaseGenCC HGNC:2022|MONDO:0010250Inferred only
non-syndromic X-linked intellectual disability has a germline basis in CLCN4DiseaseGenCC HGNC:2022|MONDO:0019181Inferred only
X-linked complex neurodevelopmental disorder has a germline basis in CLCN4DiseaseGenCC HGNC:2022|MONDO:0100148Inferred only

Statements

12 statements

12 statements · 2 reference databases · Subject: CLCN4 · Sources: Hetionet, Reactome

Order

CLCN4 participates in Ion channel transportPathwayReactome R-HSA-983712Inferred only
CLCN4 participates in Stimuli-sensing channelsPathwayReactome R-HSA-2672351Inferred only
CLCN4 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
ARF4 increases the expression of CLCN4ProteinHetionet hetionet:regulates:378-1183Inferred only
CAMSAP2 increases the expression of CLCN4ProteinHetionet hetionet:regulates:23271-1183Inferred only
CDCA4 increases the expression of CLCN4ProteinHetionet hetionet:regulates:55038-1183Inferred only
IGFBP2 increases the expression of CLCN4ProteinHetionet hetionet:regulates:3485-1183Inferred only
NOTCH1 increases the expression of CLCN4ProteinHetionet hetionet:regulates:4851-1183Inferred only
RNH1 increases the expression of CLCN4ProteinHetionet hetionet:regulates:6050-1183Inferred only
SWAP70 increases the expression of CLCN4ProteinHetionet hetionet:regulates:23075-1183Inferred only
TPI1 increases the expression of CLCN4ProteinHetionet hetionet:regulates:7167-1183Inferred only
TRAPPC3 increases the expression of CLCN4ProteinHetionet hetionet:regulates:27095-1183Inferred only

Other names

5 names

Resolves to: CLCN4

Also called: -+Chloride channel protein 4Chloride transporter ClC-4ClC-4

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