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Proteins/UNIPROT:Q9Y6H1

CHCHD2

Protein·UNIPROT:Q9Y6H1

Open in the graph

Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen)..

Function from UniProtKB (Q9Y6H1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

Parkinson disease 22, autosomal dominant has a germline basis in CHCHD2DiseaseGenCC HGNC:21645|MONDO:0014742Inferred only

Statements

18 statements

18 statements · 4 reference databases · Subject: CHCHD2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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UBC interacts with CHCHD2ProteinHetionet hetionet:interacts:51142-7316Inferred only
CHCHD2 participates in Genetic causes of porto sinusoidal vascular diseasePathwayWikiPathways WP5269Inferred only
CHCHD2 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
CHCHD2 participates in Mitochondrial protein degradationPathwayReactome R-HSA-9837999Inferred only
CHCHD2 participates in Mitochondrial protein importPathwayReactome R-HSA-1268020Inferred only
CHCHD2 participates in Protein localizationPathwayReactome R-HSA-9609507Inferred only
CHCHD2 regulates positive regulation of mitochondrial ATP synthesis coupled electron transportBiological processgene ontology Q9Y6H1|GO:1905448Inferred only
CHCHD2 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q9Y6H1|GO:0045944Inferred only
CHCHD2 regulates regulation of cellular response to hypoxiaBiological processgene ontology Q9Y6H1|GO:1900037Inferred only
CHCHD2 regulates regulation of generation of precursor metabolites and energyBiological processgene ontology Q9Y6H1|GO:0043467Inferred only
BTG2 decreases the expression of CHCHD2ProteinHetionet hetionet:regulates:7832-51142Inferred only
FADD increases the expression of CHCHD2ProteinHetionet hetionet:regulates:8772-51142Inferred only

Show the remaining 6

KEAP1 increases the expression of CHCHD2ProteinHetionet hetionet:regulates:9817-51142Inferred only
PPP3R1 increases the expression of CHCHD2ProteinHetionet hetionet:regulates:5534-51142Inferred only
RFXANK increases the expression of CHCHD2ProteinHetionet hetionet:regulates:8625-51142Inferred only
VAPB increases the expression of CHCHD2ProteinHetionet hetionet:regulates:9217-51142Inferred only
WTAP decreases the expression of CHCHD2ProteinHetionet hetionet:regulates:9589-51142Inferred only
YME1L1 decreases the expression of CHCHD2ProteinHetionet hetionet:regulates:10730-51142Inferred only

Other names

4 names

Resolves to: CHCHD2

Also called: Aging-associated gene 10 proteinC7orf17HCV NS2 trans-regulated proteinNS2TP

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