Proteins/UNIPROT:O95388

CCN4

ProteinUNIPROT:O95388

Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan..

Function from UniProtKB (O95388), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

15 statements

15 statements · 2 reference databases · Subject: CCN4 · Sources: gene ontology, Hetionet

Order

CCN4 covaries with DTX1ProteinHetionet hetionet:covaries:1840-8840Inferred only
CCN4 covaries with GPAT2ProteinHetionet hetionet:covaries:150763-8840Inferred only
BGN interacts with CCN4ProteinHetionet hetionet:interacts:633-8840Inferred only
DCN interacts with CCN4ProteinHetionet hetionet:interacts:1634-8840Inferred only
CCN4 interacts with UGGT1ProteinHetionet hetionet:interacts:56886-8840Inferred only
CCN4 regulates negative regulation of chondrocyte differentiationBiological processgene ontology O95388|GO:0032331Inferred only
CCN4 regulates negative regulation of fat cell differentiationBiological processgene ontology O95388|GO:0045599Inferred only
CCN4 regulates positive regulation of cell differentiationBiological processgene ontology O95388|GO:0045597Inferred only
CCN4 regulates positive regulation of inflammatory responseBiological processgene ontology O95388|GO:0050729Inferred only
CCN4 regulates positive regulation of osteoblast differentiationBiological processgene ontology O95388|GO:0045669Inferred only
CCN4 regulates positive regulation of smooth muscle cell migrationBiological processgene ontology O95388|GO:0014911Inferred only
CCN4 regulates positive regulation of smooth muscle cell proliferationBiological processgene ontology O95388|GO:0048661Inferred only

Show the remaining 3

CCN4 regulates positive regulation of Wnt signaling pathwayBiological processgene ontology O95388|GO:0030177Inferred only
CCN4 regulates positive regulation of wound healingBiological processgene ontology O95388|GO:0090303Inferred only
CCN4 regulates regulation of cytokine productionBiological processgene ontology O95388|GO:0001817Inferred only

Other names

4 names

Resolves to: CCN4

Also called: WISP-1WISP1Wnt-1-induced secreted proteinWNT1-inducible-signaling pathway protein 1

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